RESUMO
Abstract Background: Pemphigus constitutes a group of autoimmune bullous diseases. A reduction in the incidence of endemic pemphigus foliaceus and an increase in pemphigus vulgaris has been described, but there are no studies in Minas Gerais that address the subject. Objective: To describe the epidemiological and clinical profile of patients with pemphigus treated at the Dermatology Service of a public University Hospital in the state of Minas Gerais, Brazil. Methods: An observational, descriptive, and cross-sectional study was carried out of cases of endemic pemphigus foliaceus and pemphigus vulgaris, for a period of six months. A questionnaire was filled out with epidemiological and clinical data on the disease. Results: A total of 122 patients were included in the study, 64 with endemic pemphigus foliaceus and 58 with pemphigus vulgaris. When comparing patients with endemic pemphigus foliaceus and those with pemphigus vulgaris, a statistical difference was observed between the median age of initial disease manifestation (p = 0.001), patient occupation (p = 0.010), area of residence (p = 0.000), forests (p = 0.000) and rivers/streams close to the dwelling (p = 0.001) and the number of systemic medications required to control the disease (p = 0.002). When comparing patients with endemic pemphigus foliaceus to those evaluated in a study carried out at the same service in 2008, there was a statistical difference in the area of residence (p = 0.030). Study limitations: The assessed population comes from a tertiary care service that is not a reference for the entire state. Conclusions: Patients with endemic pemphigus foliaceus and pemphigus vulgaris maintain statistically significant differences regarding their main variables in the literature, such as age and area of residence. Historically, there has been a reduction in cases of endemic pemphigus foliaceus and an increase in cases of pemphigus vulgaris in this population.
RESUMO
A hepatite crônica causada pelo vírus C (VHC) constitui problema relevante de saúde pública no mundo. A infecção associada a esse vírus é considerada causa significativa de cirrose e respectivas complicações: hipertensão portal, descompensação da função hepática e carcinoma hepatocelular. A atividade física é amplamente incentivada no tratamento de diversas doenças crônicas. Entretanto, pouco tem sido pesquisado sobre o efeito da atividade física no curso evolutivo da hepatopatia associada ao VHC. Ainda, sabe-se que indivíduos com hepatite C crônica podem desenvolver outras afecções devido à inatividade física que podem interferir no curso da doença viral. Portanto, o objetivo do presente estudo foi realizar revisão bibliográfica sobre a relação entre atividade física e hepatite C crônica.
Chronic hepatitis caused by hepatitis C virus (HCV) is relevant for the public health problem in the world. The infection associated with this virus is considered a significant cause of cirrhosis and its complications: portal hypertension, decompensation of the liver function and hepatocellular carcinoma. Physical activity is widely encouraged in the treatment of various chronic diseases. However, little has been done on the effect of physical activity on the evolutionary course of the HCV-related liver disease. It is known that individuals with chronic hepatitis C may develop other disorders due to physical inactivity that may interfere in the course of the viral disease. Therefore, the objective of the present study was to conduct a literature review on the relationship between physical activity and chronic hepatitis C.